Response of in vitro hypoxic tumor models to potentially therapeutic compounds as revealed by an advanced analytical platform



Project number IZERZ0_142236/1 


Long-standing sicknesses that affect worldwide human beings, such as cancer have attracted the attention of the whole scientific community in order to understand for instance the genesis, propagation and elimination of cancer. Despite a great progress have been made on prognosis and cancer treatment, there are still some aspects that need to be revealed in order to have a better understanding and control of this condition. For instance, the role of different species such as carbonic anhydrases (CA) in the mechanism of generation and propagation of cancer is not completely understood and more research in this direction is still required. Precisely, in the present project a new analytical tool for the multiparametric study of hypoxic tumor models is proposed with the aim of unravelling different biological processes in cancer cells. Specifically, this new analytical platform is intended to assess the effect of different carbonic anhydrase inhibitors and its mechanism of action, which might lead to the discovery of new and more efficient anti-cancer drugs. The proposed approach is based in the synergetic combination of the knowledge and expertise that both partners have accumulated during the past years in different topics such as functional microfluidics, scanning electrochemical microscopy, mass spectrometry, surface plasmon resonance and cell handling and manipulation. Finally, it is expected that not only the delivery of a new analytical platform for cell metabolism monitoring, but also the beginning and strengthening of the collaboration between Switzerland and Romania will be an outcome of the present joint Romanian-Swiss research project.

Swiss Coordinator:  
Hubert H. Girault                                                                             
Ecole Polytechnique Fédérale de Lausanne                                                                                              
Romanian Coordinator:
Eugen Gheorghiu
International Centre of Biodynamics

Project co-financed by a grant from Switzerland through the Swiss Contribution to the enlarged European Union.